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Xefo Rapid: Fast Solution to Your Pain

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Experience rapid and effective pain relief with Xefo Rapid. This powerful medication offers fast-acting relief for a variety of painful conditions. Discover the ultimate solution to your discomfort today.

Analgesic, nonopioid; nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and acute mild to moderate painful conditions including postoperative pain.

Indication & Usage

Dose for the adults: IM, IV: Acute pain: 8 mg as a single dose (maximum: 24 mg within the first 24 hours; 16 mg/day starting on day 2). Treatment should be limited to ≤2 days. Oral: Acute pain: 8 to 16 mg/day in 2 to 3 divided doses (maximum: 16 mg/day). In the case of osteoarthritis and rheumatoid arthritis: Initial dose: 12 mg/day in 2 to 3 divided doses (maximum: 16 mg/day).

Active Ingredients

Lornoxicam

 

What you need to know before you take Xefo Rapid

Do not take Xefo Rapid

  • if you are allergic to lornoxicam or any of the other ingredients of this medicine (listed in
    section 6);
  • if you are taking other NSAIDs such as acetylsalicylic acid (for instance, aspirin);
    ibuprofen and COX-2 inhibitors;
  • if you are hypersensitive to other NSAIDs including acetylsalicylic acid (for instance,
    aspirin);
  • if you suffer from thrombocytopenia (low blood platelet count which increases risk of
    bleeding or bruising);
  • if you suffer from severe heart failure;
  • if you suffer from gastrointestinal bleeding, rupture and bleeding of a blood vessel in the
    brain, or other bleeding disorders;
  • if you have a history of gastrointestinal bleeding or perforation, related to previous
    therapy with NSAIDs;
  • if you suffer from an active peptic ulcer or have a history of recurrent peptic ulcer;
  • if you suffer from severe liver impairment;
  • if you suffer from severe kidney impairment;
  • if you are in the last three months of your pregnancy.

Dosage & Administration

Tablets are intended for oral use. Can be taken before or after meals. Taken after meals to decrease gastrointestinal upset but when taken before meals effectiveness increase, it should be taken with a sufficient amount of water.

Safety Advice

  • Should not be given to the patients who are allergic (hypersensitive) to lornoxicam.
  • Should not be given to the patients who are hypersensitive to other NSAIDs including acetylsalicylic acid (for instance aspirin).
  • Should not be given to the patients who suffer from thrombocytopenia (low blood platelet count which increases risk of bleeding or bruising)
  • Should not be given to the patients who suffer from severe heart failure -Should not be given to the patients who suffer from gastrointestinal bleeding, rupture and bleeding of a blood vessel in the brain, or other bleeding disorders.
  • Should not be given to the patients who suffer from severe liver impairment -Should not be given to the patients who suffer from severe kidney impairment.
  • Should not be given to pregnant women who are in the last three months pregnancy.
  • Avoid lornoxicam during varicella (chickenpox) infections.
  • Not recommended for use in children under 18 years of age.
  • Not recommended for use in elderly people that are over 65 years of age.
  • Incase of over dose be ready to tell or show what was taken, how much and when it happened, and seek immediate medical attention.

Storage

Store at room temperature.

Drug Interactions

  • Lornoxicam may interfere with other medicines like the following:
  • Cimetidine – used in the treatment of heartburn and peptic ulcers;
  • Anticoagulants, such as heparin or phenprocoumon – used to prevent the formation of blood clot
  • Corticosteroids -Methotrexate – used in treatment of cancer and immunological diseases
  • Immunosuppressive agents, such as ciclosporine or tacrolimus
  • Heart medicines, such as digoxin, ACE inhibitors, beta-adrenergic blockers;
  • Lithium
  • Diuretics
  • Quinolone antibiotics
  • Anti-platelet agents – medicines used to prevent heart attacks and stroke
  • SSRI (Selective Serotonin Reuptake Inhibitors) – used in the treatment of depression
  • Sulphonylureas, for instance glibenclamide – used in the management of diabetes
  • Angiotensin II receptor blocker

 

Xefo Rapid with food and drink

Xefo Rapid film-coated tablets are intended for oral use. Take this medicine before meals with a
sufficient amount of liquid.
Taking this medicine with food is not recommended because this may reduce its effectiveness.

Pregnancy, breast-feeding and fertility

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby,
ask your doctor or pharmacist for advice before taking this medicine.

Fertility

Using Xefo Rapid may impair fertility and is not recommended for women attempting to
become pregnant. Women who have difficulties becoming pregnant, or who are undergoing
investigation of infertility, should consult with a doctor and consider stopping treatment with Xefo Rapid.

Pregnancy

During the first 6 months of pregnancy treatment with Xefo Rapid is not recommended, unless
explicitly advised by your doctor.
You must not take Xefo Rapid during the last three months of your pregnancy.

Breast-feeding

If you are breast-feeding treatment with Xefo Rapid is not recommended, unless explicitly advised by your doctor.

Driving and using machines

Xefo Rapid has negligible or no influence on the ability to drive or use

 

How to take Xefo Rapid

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
The usual dose for adults is 8-16 mg divided in doses of 8 mg: 8 mg taken twice a day or 16 mg taken once a day.
On the first day you take Xefo Rapid the dose can be 16 mg followed by 8 mg 12 hours later.

After the first day do not take more than 16 mg a day.

Xefo Rapid tablets must be swallowed with sufficient amounts of liquid.

Do not take Xefo Rapid with a meal, as food can reduce the effectiveness of Xefo Rapid.
Xefo Rapid is not recommended for children and adolescents below 18 years old, due to lack of data.

If you take more Xefo Rapid than you should

Please contact your doctor or the pharmacist if you have taken more Xefo Rapid than prescribed.
In case of an overdose, you may expect the following symptoms: nausea, vomiting, symptoms associated with central nervous system (such as dizziness or disturbances in vision).

If you forget to take Xefo Rapid

Do not take a double dose to make up for a forgotten tablet.
If you have any further questions on the use of this product, ask your doctor or pharmacist.

 

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Medicines such as Xefo Rapid may be associated with a small increase in the risk of heart attack or stroke.

If you experience any unusual abdominal symptoms such as abdominal bleeding, skin reactions
such as skin rash, damage to the internal lining of the nostrils, mouth, eyelids, ears, genitals or anus, or other signs of hypersensitivity, you should stop taking Xefo and contact your doctor immediately.

If you get any of the following side effects, stop taking this medicine and tell your doctor immediately, or contact the emergency department at your nearest hospital:

  • shortness of breath, chest pains, or ankle swelling appear or get worse;
  • severe or continuous stomach pain or your stools become black;
  • yellowing of the skin and eyes (jaundice) – these are signs of liver problems;
  • an allergic reaction – which can include skin problems such as ulcers or blistering, or swelling of the face, lips, tongue, or throat which may cause difficulty in breathing;
  • fever, blistering eruption or inflammation especially on hands and feet or in the mouth area (Stevens-Johnson syndrome);
  • exceptionally, serious infections of the skin in case of varicella (chickenpox).

Undesirable effects associated with using Xefo Rapid are given below.

Common side effects (may affect up to 1 in 10 people)

  • mild and passing headache and dizziness,
  • nausea, abdominal pain, upset stomach, diarrhoea and vomiting.

Uncommon side effects (may affect up to 1 in 100 people)

  • weight loss (anorexia), inability to sleep, depression;
  • eye discharges (conjunctivitis);
  • feeling dizzy, ringing in the ears (tinnitus);
  • cardiac failure, irregular heartbeat, rapid heart rate, feeling blushed;
  • constipation, excessive wind (flatulence), belching, dry mouth, gastritis, peptic ulcer, upper abdominal pain, duodenal ulcer, mouth ulcers;
  • increase in liver function tests (as seen from blood tests) and feeling unwell (malaise);
  • rash, itching, increased sweating, redness of the skin (erythema), angiooedema (rapid swelling of the deeper layers of skin, usually of the face), hives (urticaria), oedema, stuffy nose as a result of an allergy (rhinitis);
  • hair loss;
  • arthralgia (pain in the joints).

Rare side effects (may affect up to 1 in 1,000 people)

  • sore throat;
  • anaemia, reduction in the blood cell count (thrombocytopenia and leukopenia), weakness;
  • hypersensitivity, anaphylactoid reaction and anaphylaxis (organism reaction characterized usually by face swelling, flushing, difficulties breathing and lightheadedness);
  • confusion, nervousness, agitation, feeling sleepy (somnolence), paraesthesia (tingling sensations), abnormal sense of taste, tremor, migraine, visual disturbances;
  • elevated blood pressure, hot flush;
  • bleeding, haematoma (bruising), prolonged bleeding time;
  • difficulty in breathing (dyspnoea), cough, bronchospasm;
  • perforated ulcer, vomiting of blood, gastrointestinal bleeding, black tarry stools;
  • inflammation in the mouth, oesophagitis (inflammation of the gullet), gastro-oesophageal reflux, difficulty in swallowing, aphthous stomatitis (ulcers), inflammation of the tongue,
  • abnormal liver function;
  • skin problems, such as eczema, rash;
  • bone pain, muscle cramp, muscle pain;
  • urinary problems, such as the need to wake up and urinate during the night (nocturnia) or an increase in the levels of urea and creatinine in the blood.

Very rare side effects (may affect up to 1 in 10,000 people)

  • liver damage, hepatitis (inflammation of the liver), jaundice, cholestasis (interrupted flow of bile from the liver);
  • bruising, oedema, severe skin disorder (Stevens-Johnson syndrome, Toxic epidermal necrolysis);
  • aseptic meningitis;
  • NSAID class effects: neutropenia, agranulocytosis, aplastic anaemia, hemolytic anaemia, kidney toxicity.

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