G6PD is an inherited X-linkded recessive genetic disorder, haemolysis results from oxidative damage to RBCs due to loss of protective effect of the enzyme G6PD.
Clinical Features:
- Usually asymptomatic but liable to haemolysis if infection, incriminated drugs or foods are taken (e.g. sulphonamides, fava beans, tabs chloroquine or proguanil).
- Pallor, jaundice and dark urine(Coca-colored urine)
Laboratory findings
Anaemia, peripheral smear-normocytic normochromic, spherocytes, bite cell,
Reticlocytosis, Heinz bodies, Positive Ham’s test
Non-pharmacological Treatment
- Avoid incriminated agents/foods or drugs
- Transfusion of packed red blood cells in severe anaemia. Give 10ml/kg body weight over a period of 8 hours. Then assess the level of haemoglobin.
Pharmacological Treatment
A: Folic acid 5mg (PO) once daily for 1 month
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